In my layman’s attempt at helping my son with the anxiety and depression that he was thrown into in his early high school days, I’ve come across numerous helpful things, certainly not all of them will help everyone, but they have helped him and they are worth considering.  These two forms of Vitamin B, Methylcobolamine and Methyfolate can combat the effects of gene mutations on the Methylenetetrahydrofolate reductase genes (you can see where it gets the nickname that looks like it needs to be bleeped), according to Dr Stephen Gundry in his book The Plant Paradox.  According to Dr. Gundry about half the world’s population has one or more mutations on the MTHFR genes that cause a host of health issues, and contribute to anxiety and depression.  These two forms of Vitamin B specifically bind to an amino acid called homocysteine in your bloodstream converting it into a harmless substance.  Whereas, left unchecked, it can damage blood vessels.  Dr. Gundry recommends 1000 to 5000 of  methylcobalamine sublingually (under your tongue) per day and 1000 mcg of methyfolate per day.  More information can be found on his site (www.DrGundry.com) and in his book, The Plant Paradox. He does mention that for individuals with a double mutation of the gene that the B vitamins can cause adverse reactions.  Get more information before you decide if this is right for you.  There is genetic testing available that can help you decide if this is a good choice for your circumstances.